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Chr6 26M-27M

Methodology

In an attempt to narrow the DecodeME1 GWAS-1 signal, I fine-mapped the first hit on chromosome 6 using SUSIE2. The parameters of my SUSIE runs were the same as for the chromosome 1 hit

None of the SUSIE runs at this locus found any credible sets. Given that this locus lies in the HLA region, which is notorious for its complex LD structure, this result is perhaps unsurprising.

  1. Genetics Delivery Team, Thibaud Boutin, Andrew D Bretherick, Joshua J Dibble, Esther Ewaoluwagbemiga, Emma Northwood, Gemma L Samms, Veronique Vitart, Project, Cohort Delivery Team, Øyvind Almelid, and others. Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome. medRxiv, pages 2025–08, 2025. URL: https://www.medrxiv.org/content/10.1101/2025.08.06.25333109v1. ↩

  2. Gao Wang, Abhishek Sarkar, Peter Carbonetto, and Matthew Stephens. A simple new approach to variable selection in regression, with application to genetic fine mapping. Journal of the Royal Statistical Society Series B: Statistical Methodology, 82(5):1273–1300, 2020. URL: https://academic.oup.com/jrsssb/article/82/5/1273/7056114. ↩