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DCC

NCBI Description

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Other Linked Conditions

  • Mono and Polyneuropathy1

  1. Martin Broberg, Finn Gen, Eija Kalso, and Hanna M Ollila. Genome-wide meta-analysis identifies genetic risk loci for mono-and polyneuropathies in 983 477 individuals. Human Molecular Genetics, pages ddaf200, 2026. URL: https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddaf200/8419672. ↩