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S-LDSC Analysis

I applied Stratified Linkage Disequilibrium Score Regression1 (S-LDSC) to Kamitaki et al.'s GWAS of Human Herpesvirus 7 DNA levels2. There were no significant cell types in any of the datasets. It is interesting to contrast this the corresponding analysis for EBV DNA levels, which produced several significant cells types. This may indicate an overall weaker signal in the HHV7 GWAS.

  1. Hilary K Finucane, Yakir A Reshef, Verneri Anttila, Kamil Slowikowski, Alexander Gusev, Andrea Byrnes, Steven Gazal, Po-Ru Loh, Caleb Lareau, Noam Shoresh, and others. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nature Genetics, 50(4):621–629, 2018. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC5896795/. ↩

  2. Nolan Kamitaki, David Tang, Steven A McCarroll, and Po-Ru Loh. Genes and environment profoundly affect the human virome. bioRxiv, pages 2025–09, 2025. URL: https://www.biorxiv.org/content/10.1101/2025.09.08.674901. ↩