Skip to content

MAGMA GTEx

I applied MAGMA analysis to the Verweiji et al.'s GWAS of heart rate recovery after exercise1, using GTEx bulk RNAseq data2 as a reference.

Results

The results are shown in the bar plot below: verweiji_gtex_magma

There are two significant tissue types: the atrial appendage and the gastroesophageal junction. The atrial appendage may be stand-in for cardiac tissue in general, and could reflect the role of general heart health in recovery from exercise. Alternatively, this could reflect the importance of pacemaker cells near the atrial appendage in controlling heart rate. The significance of the gastroesophageal junction is unclear.

  1. Niek Verweij, Yordi J van de Vegte, and Pim van der Harst. Genetic study links components of the autonomous nervous system to heart-rate profile during exercise. Nature Communications, 9(1):898, 2018. ↩

  2. GTEx Consortium. The GTEx consortium atlas of genetic regulatory effects across human tissues. Science, 369(6509):1318–1330, 2020. URL: https://www.science.org/doi/full/10.1126/science.aaz1776. ↩