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Corces et al. Blood Cell Epigenetics

corces_diagram

Diagram from Corces et al.1 showing 5 important ATAC-seq regions for each of 13 blood cell types.

In their 2016 paper, Corces et al.1 used ATAC-seq to record epigenetic chromatin accessibility data from 13 blood-cell types.

Using functional genomics techniques like MAGMA and S-LDSC, this cell-specific chromatin accessibility data can be combined with GWAS summary statistics to implicate specific blood cell types in specific phenotypes.

  1. M Ryan Corces, Jason D Buenrostro, Beijing Wu, Peyton G Greenside, Steven M Chan, Julie L Koenig, Michael P Snyder, Jonathan K Pritchard, Anshul Kundaje, William J Greenleaf, and others. Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution. Nature Genetics, 48(10):1193–1203, 2016. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC5042844/. ↩↩