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ImmGen

Immgen-visualization

Image source: Aguilar et al.1

The ImmGen project1 is a public resource describing gene expression and gene regulation in the mouse immune system. For each cell type in a highly granular taxonomy of mouse immune cell types, the ImmGen project seeks to record:

  • mRNA expression levels,
  • Epigenetic information describing chromatin regulation,
  • Information on the relationship between mRNA and protein levels.

Uses

Because of its extreme granularity, and because of the similarity between the mouse and human immune systems, ImmGen reference data can be combined with GWAS summary statistics to suggest the key immune-system cells driving a phenotype.

  1. Stephanie Vargas Aguilar, Oscar Aguilar, Rhys Allan, El Ad David Amir, Veronique Angeli, Maxim N Artyomov, Natasha Asinovski, Jilian Astarita, K Frank Austen, Geetika Bajpai, and others. ImmGen at 15. Nature Immunology, 21(7):700–703, 2020. URL: https://escholarship.org/content/qt75r8v4bt/qt75r8v4bt.pdf. ↩↩