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S-LDSC

I applied Stratified Linkage Disequilibrium Score Regression1 (S-LDSC) to summary statistics from Said et al.'s GWAS of CRP2. Surprisingly, and in contrast to the MAGMA results, there were no significant hits with any of the standard S-LDSC reference datasets.

  1. Hilary K Finucane, Yakir A Reshef, Verneri Anttila, Kamil Slowikowski, Alexander Gusev, Andrea Byrnes, Steven Gazal, Po-Ru Loh, Caleb Lareau, Noam Shoresh, and others. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nature Genetics, 50(4):621–629, 2018. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC5896795/. ↩

  2. Saredo Said, Raha Pazoki, Ville Karhunen, Urmo Võsa, Symen Ligthart, Barbara Bodinier, Fotios Koskeridis, Paul Welsh, Behrooz Z Alizadeh, Daniel I Chasman, and others. Genetic analysis of over half a million people characterises C-reactive protein loci. Nature Communications, 13(1):2198, 2022. URL: https://www.nature.com/articles/s41467-022-29650-5. ↩