S-LDSC

I applied Stratified Linkage Disequilibrium Score Regression (S-LDSC)¹ to summary statistics from DecodeME² GWAS-1.

Reference Data Sources

I used the standard reference datasets prepared by the authors of the S-LDSC method.

• The GTEx Project
• The Franke lab dataset
• The Roadmap Epigenetic Project and the ENCODE project.
• The Corces et al. ATAC-seq dataset of 13 blood cell types.
• The ImmGen Project
• The Cahoy Mouse Central Nervous System Dataset

Results

GTEx and Franke lab tissue expression data

The plot and expandable table below show the results of S-LDSC applied to DecodeME using the GTEx and Franke lab gene expression reference datasets. In the plot, the x-axis corresponds to cell type, while the y-axis corresponds to \(-\log_{10}(p)\). Points are colored according to tissue category. Large points indicate cell/tissue types deemed significant by the Benjamini-Hochberg procedure at an FDR of 0.01³.

Fullscreen Plot ⤢

GTEx and Franke lab tissue expression — full results

Name	Coefficient	Coefficient_P_value	Reject Null
A08.186.211.Brain	4.73506e-09	2.33404e-07	True
A08.186.211.730.885.287.500.571.735.Visual.Cortex	4.51424e-09	1.50744e-06	True
A08.186.211.464.405.Hippocampus	4.49844e-09	2.03572e-06	True
Brain_Cortex	3.66785e-09	2.34659e-06	True
A08.186.211.730.885.287.500.270.Frontal.Lobe	4.64871e-09	2.4708e-06	True
Brain_Nucleus_accumbens_(basal_ganglia)	3.59693e-09	3.28173e-06	True
Brain_Frontal_Cortex_(BA9)	3.69318e-09	3.39435e-06	True
A08.186.211.464.710.225.Entorhinal.Cortex	4.15918e-09	5.7566e-06	True
A08.186.211.730.885.287.500.Cerebral.Cortex	4.18585e-09	5.82171e-06	True
A08.186.211.464.Limbic.System	4.21669e-09	6.15801e-06	True
Brain_Substantia_nigra	3.51819e-09	7.82653e-06	True
Brain_Anterior_cingulate_cortex_(BA24)	3.2648e-09	1.02383e-05	True
Brain_Amygdala	3.19978e-09	2.50699e-05	True
Brain_Hippocampus	3.27734e-09	2.72461e-05	True
Brain_Caudate_(basal_ganglia)	3.12103e-09	7.86476e-05	True
Brain_Putamen_(basal_ganglia)	3.11623e-09	0.000106439	True
A08.186.211.730.317.357.352.435.Hypothalamo.Hypophyseal.System	3.60073e-09	0.000181506	True
A08.186.211.730.317.357.Hypothalamus	3.23283e-09	0.000225723	True
A08.186.211.730.885.287.500.670.Parietal.Lobe	3.47013e-09	0.000239049	True
Brain_Hypothalamus	2.85088e-09	0.00033006	True
A08.186.211.730.317.Diencephalon	3.01633e-09	0.000332194	True
Brain_Cerebellar_Hemisphere	2.68265e-09	0.000576615	True
A08.186.211.730.885.287.249.Basal.Ganglia	2.68514e-09	0.00131033	False
A08.186.211.865.428.Metencephalon	2.43922e-09	0.00193903	False
A08.186.211.653.Mesencephalon	2.46348e-09	0.00514773	False
Brain_Cerebellum	2.22371e-09	0.0051628	False
A08.186.211.730.885.287.249.487.Corpus.Striatum	2.25582e-09	0.00520539	False
Brain_Spinal_cord_(cervical_c-1)	2.08681e-09	0.00631206	False
A08.186.211.132.810.428.200.Cerebellum	2.13097e-09	0.00635224	False
A08.186.211.132.Brain.Stem	1.85595e-09	0.0148055	False
A09.371.729.Retina	1.67487e-09	0.0500144	False
A11.872.653.Neural.Stem.Cells	1.80156e-09	0.0519904	False
A15.382.Immune.System	1.69211e-09	0.071954	False
A15.382.490.555.567.Lymphocytes	1.68552e-09	0.0726655	False
Pituitary	1.06153e-09	0.126352	False
A11.436.348.Hepatocytes	1.283e-09	0.130431	False
A06.407.312.782.Testis	1.03966e-09	0.134204	False
A10.615.789.Serous.Membrane	1.27581e-09	0.136899	False
A14.549.885.Tongue	1.2945e-09	0.13815	False
A11.118.637.555.567.569.200.700.T.Lymphocytes..Regulatory	9.518e-10	0.193115	False
A03.556.500.760.464.Parotid.Gland	8.43908e-10	0.206871	False
Esophagus_Muscularis	7.58574e-10	0.222816	False
A11.872.190.260.Embryoid.Bodies	7.71889e-10	0.226258	False
Fallopian_Tube	5.39735e-10	0.257251	False
A14.724.Pharynx	6.49731e-10	0.275774	False
Esophagus_Gastroesophageal_Junction	5.36082e-10	0.282294	False
A15.382.520.604.800.Palatine.Tonsil	5.82167e-10	0.283822	False
A15.145.Blood	6.64555e-10	0.287035	False
A15.145.229.637.555.Leukocytes..Mononuclear	6.1388e-10	0.294278	False
A14.549.Mouth	5.75192e-10	0.295617	False
A03.556.249.249.356.668.Colon..Sigmoid	6.15956e-10	0.307957	False
A15.145.300.Fetal.Blood	5.45979e-10	0.326384	False
A02.633.567.850.Quadriceps.Muscle	5.07856e-10	0.326843	False
A15.382.812.Mononuclear.Phagocyte.System	4.5181e-10	0.336561	False
A11.118.637.555.567.562.B.Lymphocytes	4.25592e-10	0.345866	False
A05.360.319.679.256.Cervix.Uteri	3.78787e-10	0.35949	False
A11.118.637.Leukocytes	3.78997e-10	0.362955	False
A15.145.229.637.555.567.569.200.CD4.Positive.T.Lymphocytes	3.67096e-10	0.368099	False
A11.627.624.249.Monocyte.Macrophage.Precursor.Cells	3.56749e-10	0.369628	False
Thyroid	2.94776e-10	0.37154	False
A11.118.637.555.567.562.440.Precursor.Cells..B.Lymphoid	3.03869e-10	0.374309	False
Bladder	2.55089e-10	0.378013	False
Minor_Salivary_Gland	2.53576e-10	0.389364	False
Prostate	2.60301e-10	0.395431	False
A15.382.812.522.Macrophages	2.89075e-10	0.399577	False
A03.556.500.760.Salivary.Glands	2.48207e-10	0.403099	False
A02.835.583.443.800.800.Synovial.Fluid	2.83649e-10	0.408081	False
A11.436.397.Keratinocytes	2.23011e-10	0.414852	False
A15.382.490.555.567.537.Killer.Cells..Natural	2.04772e-10	0.420233	False
A11.872.378.590.635.Granulocyte.Macrophage.Progenitor.Cells	1.74033e-10	0.436667	False
Cervix_Endocervix	1.26288e-10	0.446412	False
A14.724.557.Nasopharynx	1.30716e-10	0.44855	False
Uterus	1.07972e-10	0.453726	False
A09.371.Eye	1.05812e-10	0.457101	False
A11.118.637.555.567.569.T.Lymphocytes	1.08788e-10	0.45861	False
Heart_Atrial_Appendage	8.68427e-11	0.461942	False
A03.556.875.Upper.Gastrointestinal.Tract	8.66548e-11	0.469568	False
A03.556.875.500.Esophagus	6.7693e-11	0.474928	False
A06.407.900.Thyroid.Gland	4.46941e-11	0.480578	False
Muscle_Skeletal	-9.27722e-12	0.503907	False
Testis	-3.30531e-11	0.513338	False
Heart_Left_Ventricle	-5.36533e-11	0.52118	False
Spleen	-6.51304e-11	0.52633	False
A15.145.229.Blood.Cells	-8.32983e-11	0.530874	False
Ovary	-7.73972e-11	0.539266	False
A05.360.Genitalia	-1.03433e-10	0.541436	False
A05.360.319.Genitalia..Female	-1.04391e-10	0.544695	False
A03.556.124.526.767.Rectum	-1.49828e-10	0.549742	False
A06.407.312.Gonads	-1.42137e-10	0.55752	False
A10.615.550.599.Mouth.Mucosa	-1.77426e-10	0.568035	False
A11.443.Erythroid.Cells	-1.64428e-10	0.573435	False
A15.382.490.315.583.Neutrophils	-2.74189e-10	0.627011	False
A15.378.316.580.Monocytes	-3.67572e-10	0.632929	False
Cells_EBV-transformed_lymphocytes	-3.5895e-10	0.634436	False
A10.690.Muscles	-3.63394e-10	0.635045	False
A03.556.249.249.209.Cecum	-4.1654e-10	0.638912	False
A15.378.316.Bone.Marrow.Cells	-3.87637e-10	0.645568	False
A14.549.167.646.Periodontium	-3.90601e-10	0.647928	False
Nerve_Tibial	-3.02964e-10	0.653482	False
A06.407.Endocrine.Glands	-4.08215e-10	0.655632	False
A10.272.497.Epidermis	-4.45981e-10	0.665926	False
A15.145.229.188.Blood.Platelets	-5.04225e-10	0.686229	False
A14.549.167.Dentition	-4.78352e-10	0.690781	False
A11.329.372.600.Macrophages..Alveolar	-5.22858e-10	0.696034	False
A03.556.875.875.Stomach	-5.89692e-10	0.698687	False
A11.436.329.Granulosa.Cells	-4.89696e-10	0.703879	False
Cervix_Ectocervix	-5.05736e-10	0.708895	False
A05.360.319.114.373.Fallopian.Tubes	-5.57515e-10	0.716433	False
A10.549.Lymphoid.Tissue	-6.1561e-10	0.71846	False
A05.360.319.679.490.Endometrium	-4.97914e-10	0.720116	False
A11.627.340.360.Granulocyte.Precursor.Cells	-5.81466e-10	0.730433	False
A11.872.378.590.817.Megakaryocyte.Erythroid.Progenitor.Cells	-5.42493e-10	0.737822	False
A05.360.319.679.Uterus	-5.24673e-10	0.739093	False
A11.872.378.Hematopoietic.Stem.Cells	-5.98039e-10	0.748675	False
A05.360.319.114.630.Ovary	-6.54949e-10	0.75057	False
A15.382.812.260.Dendritic.Cells	-6.68024e-10	0.75416	False
A10.615.550.Mucous.Membrane	-6.41732e-10	0.754797	False
Lung	-6.43855e-10	0.766715	False
Liver	-6.63293e-10	0.769567	False
A11.627.635.Myeloid.Progenitor.Cells	-7.35424e-10	0.778261	False
A11.872.190.Embryonic.Stem.Cells	-8.64428e-10	0.813379	False
A05.810.453.Kidney	-8.29504e-10	0.820158	False
Stomach	-8.71285e-10	0.8213	False
A15.145.229.637.555.567.562.725.Plasma.Cells	-9.66746e-10	0.825632	False
Colon_Sigmoid	-8.62426e-10	0.830335	False
A05.810.453.324.Kidney.Cortex	-9.32073e-10	0.834727	False
A11.872.040.Adult.Stem.Cells	-8.74444e-10	0.840611	False
A03.556.124.369.Intestinal.Mucosa	-1.02831e-09	0.840852	False
A11.436.Epithelial.Cells	-9.99687e-10	0.843176	False
A07.541.358.Heart.Atria	-9.09139e-10	0.848811	False
Colon_Transverse	-9.1958e-10	0.854084	False
A10.615.Membranes	-9.76808e-10	0.865416	False
A03.620.Liver	-1.0177e-09	0.867439	False
A10.165.450.300.Cicatrix	-8.80553e-10	0.873532	False
A15.382.680.Phagocytes	-1.12622e-09	0.874241	False
A17.815.Skin	-1.1477e-09	0.885937	False
A10.549.400.Lymph.Nodes	-1.26e-09	0.891273	False
A15.382.490.555.567.622.Lymphocytes..Null	-1.23493e-09	0.89473	False
Artery_Coronary	-1.01124e-09	0.897515	False
A15.145.846.Serum	-1.26445e-09	0.897642	False
Adrenal_Gland	-1.05643e-09	0.898274	False
A06.407.071.Adrenal.Glands	-1.1935e-09	0.89976	False
A11.329.629.Osteoblasts	-1.19376e-09	0.900717	False
Esophagus_Mucosa	-1.07781e-09	0.901754	False
Artery_Aorta	-1.24401e-09	0.908326	False
Whole_Blood	-1.25402e-09	0.914834	False
Kidney_Cortex	-1.21996e-09	0.925866	False
A05.810.890.Urinary.Bladder	-1.51298e-09	0.925922	False
A03.556.124.684.Intestine..Small	-1.73947e-09	0.934563	False
A11.382.Endocrine.Cells	-1.32221e-09	0.937151	False
A07.541.358.100.Atrial.Appendage	-1.35594e-09	0.93774	False
A07.541.560.Heart.Ventricles	-1.37328e-09	0.939421	False
A02.165.Cartilage	-1.406e-09	0.939982	False
A10.165.450.300.425.Keloid	-1.27563e-09	0.944139	False
A03.556.Gastrointestinal.Tract	-1.54997e-09	0.946094	False
A10.272.Epithelium	-1.56878e-09	0.946373	False
A10.336.707.Prostate	-1.49741e-09	0.946991	False
A05.360.490.Germ.Cells	-1.43773e-09	0.949766	False
A15.382.520.604.700.Spleen	-1.56886e-09	0.95448	False
A06.407.071.140.Adrenal.Cortex	-1.58842e-09	0.95654	False
A11.872.Stem.Cells	-1.61989e-09	0.957078	False
A10.165.114.830.500.750.Subcutaneous.Fat..Abdominal	-1.48944e-09	0.959206	False
A03.556.124.Intestines	-1.81283e-09	0.959429	False
A11.497.497.600.Oocytes	-1.43737e-09	0.962082	False
A10.165.114.830.750.Subcutaneous.Fat	-1.50907e-09	0.964146	False
Skin_Sun_Exposed_(Lower_leg)	-1.71344e-09	0.965135	False
A05.360.319.887.Vulva	-1.6874e-09	0.965581	False
A10.690.467.Muscle..Smooth	-1.80711e-09	0.965873	False
A11.329.830.Stromal.Cells	-1.73036e-09	0.96626	False
A11.872.700.500.Induced.Pluripotent.Stem.Cells	-1.55288e-09	0.966599	False
A03.556.249.249.356.Colon	-1.9052e-09	0.967461	False
A07.541.Heart	-1.57712e-09	0.9675	False
A11.620.520.Myocytes..Smooth.Muscle	-1.75976e-09	0.96797	False
A07.231.114.Arteries	-1.6889e-09	0.969583	False
A03.556.249.124.Ileum	-2.21533e-09	0.974825	False
A04.531.520.Nasal.Mucosa	-1.99277e-09	0.975396	False
A05.360.444.Genitalia..Male	-1.90874e-09	0.976393	False
Skin_Not_Sun_Exposed_(Suprapubic)	-1.89423e-09	0.977624	False
A05.360.319.679.690.Myometrium	-1.80782e-09	0.978176	False
A02.835.232.834.151.Cervical.Vertebrae	-1.77502e-09	0.981935	False
Artery_Tibial	-1.75609e-09	0.986554	False
Adipose_Visceral_(Omentum)	-1.8551e-09	0.989519	False
A11.872.580.Mesenchymal.Stem.Cells	-2.04717e-09	0.991783	False
A11.329.114.Adipocytes	-2.16051e-09	0.99321	False
Vagina	-2.26041e-09	0.995365	False
Pancreas	-2.24011e-09	0.996089	False
Small_Intestine_Terminal_Ileum	-2.59946e-09	0.996097	False
A07.231.908.Veins	-2.40412e-09	0.9961	False
A11.329.171.Chondrocytes	-2.35282e-09	0.996889	False
A11.436.294.064.Glucagon.Secreting.Cells	-2.7665e-09	0.997038	False
Cells_Transformed_fibroblasts	-2.31957e-09	0.99718	False
Breast_Mammary_Tissue	-2.20053e-09	0.99804	False
A03.734.414.Islets.of.Langerhans	-3.07302e-09	0.998649	False
Adipose_Subcutaneous	-2.34878e-09	0.998793	False
A07.541.510.110.Aortic.Valve	-2.57692e-09	0.999023	False
A07.231.908.670.874.Umbilical.Veins	-2.99038e-09	0.99937	False
A07.231.Blood.Vessels	-3.2857e-09	0.999434	False
A05.360.444.492.362.Foreskin	-2.70121e-09	0.99957	False
A02.835.583.443.800.Synovial.Membrane	-2.90027e-09	0.999637	False
A11.329.228.Fibroblasts	-3.05686e-09	0.999825	False
A11.329.Connective.Tissue.Cells	-3.27306e-09	0.999864	False
A11.436.275.Endothelial.Cells	-3.42995e-09	0.999955	False
A04.411.Lung	-3.85806e-09	0.999998	False
A10.615.284.473.Chorion	-3.77955e-09	0.999998	False
A03.734.Pancreas	-3.59573e-09	0.999999	False

As we saw in GTEx MAGMA analysis, the significant tissues are all CNS-related.

Roadmap/ ENCODE Chromatin data

I next applied S-LDSC using the Roadmap epigenetic reference dataset. The results are in the plot and expandable table below:

Fullscreen Plot ⤢

Roadmap chromatin — full results

Name	Coefficient	Coefficient_P_value	Reject Null
Fetal_Brain_Female__DNase	1.02258e-07	6.02085e-10	True
Brain_Dorsolateral_Prefrontal_Cortex__H3K27ac	5.08031e-08	1.52254e-09	True
Fetal_Brain_Male__DNase	9.54334e-08	2.15217e-09	True
Brain_Dorsolateral_Prefrontal_Cortex__H3K4me3	1.70618e-07	5.86939e-09	True
Fetal_Brain_Male__H3K4me1	3.7635e-08	7.78546e-09	True
Fetal_Brain_Female__H3K4me1	6.17759e-08	1.80065e-08	True
Brain_Anterior_Caudate__H3K27ac	3.87651e-08	3.4199e-08	True
Brain_Inferior_Temporal_Lobe__H3K27ac	3.30894e-08	2.61058e-07	True
Brain_Cingulate_Gyrus__H3K9ac	8.7628e-08	3.05704e-07	True
Brain_Angular_Gyrus__H3K9ac	8.4116e-08	7.91868e-07	True
Brain_Dorsolateral_Prefrontal_Cortex__H3K4me1	5.21462e-08	2.0419e-06	True
Brain_Germinal_Matrix__H3K4me3	1.25843e-07	2.75657e-06	True
Brain_Inferior_Temporal_Lobe__H3K4me3	1.03673e-07	3.90355e-06	True
Brain_Anterior_Caudate__H3K4me3	1.02925e-07	5.37695e-06	True
Fetal_Brain_Female__H3K4me3	1.26315e-07	6.40638e-06	True
Brain_Dorsolateral_Prefrontal_Cortex__H3K9ac	9.38796e-08	7.31638e-06	True
Brain_Angular_Gyrus__H3K4me3	1.29954e-07	1.03721e-05	True
Brain_Cingulate_Gyrus__H3K4me3	1.07277e-07	1.07895e-05	True
Brain_Angular_Gyrus__H3K4me1	4.09021e-08	1.44814e-05	True
Brain_Angular_Gyrus__H3K27ac	3.26629e-08	1.8453e-05	True
Brain_Cingulate_Gyrus__H3K27ac	2.93887e-08	2.78984e-05	True
Brain_Anterior_Caudate__H3K9ac	6.35807e-08	3.03752e-05	True
Brain_Anterior_Caudate__H3K4me1	3.54746e-08	3.89261e-05	True
Brain_Cingulate_Gyrus__H3K4me1	3.23616e-08	4.06924e-05	True
Brain_Inferior_Temporal_Lobe__H3K9ac	5.55958e-08	8.76778e-05	True
Cortex_derived_primary_cultured_neurospheres__H3K4me3	1.29715e-07	9.80473e-05	True
Ganglion_Eminence_derived_primary_cultured_neurospheres__H3K4me3	9.43176e-08	0.000117423	True
Brain_Hippocampus_Middle__H3K4me3	6.52668e-08	0.000227983	True
Brain_Inferior_Temporal_Lobe__H3K4me1	3.40931e-08	0.000335513	True
Brain_Hippocampus_Middle__H3K4me1	2.00405e-08	0.000347557	True
Fetal_Brain_Female__H3K36me3	3.1696e-08	0.000604661	True
Brain_Germinal_Matrix__H3K4me1	4.78491e-08	0.000700161	False
skeletal_muscle_ENTEX__H3K4me1	1.16176e-08	0.000893301	False
Brain_Substantia_Nigra__H3K4me3	7.33401e-08	0.00117193	False
Brain_Hippocampus_Middle__H3K27ac	1.93276e-08	0.00158577	False
Placenta_Amnion__H3K36me3	2.51388e-08	0.00164356	False
Brain_Dorsolateral_Prefrontal_Cortex__H3K36me3	3.51506e-08	0.00171148	False
Ganglion_Eminence_derived_primary_cultured_neurospheres__H3K4me1	3.15058e-08	0.00231774	False
Brain_Substantia_Nigra__H3K9ac	4.31037e-08	0.00337633	False
skeletal_muscle_ENTEX__H3K27ac	8.27165e-09	0.00340279	False
Brain_Germinal_Matrix__H3K36me3	3.48999e-08	0.00375125	False
Psoas_Muscle__DNase	3.55877e-08	0.00630604	False
Brain_Angular_Gyrus__H3K36me3	3.18207e-08	0.00682918	False
Brain_Substantia_Nigra__H3K4me1	1.71248e-08	0.00715837	False
Heart-LV_ENTEX__H3K4me3	5.63499e-08	0.0100419	False
Cortex_derived_primary_cultured_neurospheres__H3K4me1	1.69371e-08	0.0138721	False
Foreskin_Melanocyte_Primary_Cells_skin01__H3K27ac	4.12312e-08	0.0180246	False
Esoph-Muscularis_ENTEX__H3K4me1	1.37829e-08	0.0202165	False
Gastric__H3K4me3	5.46753e-08	0.0206406	False
Brain_Substantia_Nigra__H3K27ac	1.17715e-08	0.0248236	False
Psoas_Muscle__H3K27ac	2.20949e-08	0.0287484	False
Spleen__H3K4me1	1.85287e-08	0.0291364	False
Mammary_ENTEX__H3K36me3	1.5748e-08	0.0305984	False
Heart-Atrial_ENTEX__H3K27ac	1.05022e-08	0.0321738	False
Brain_Anterior_Caudate__H3K36me3	2.21178e-08	0.0325249	False
Esoph-Mucosa_ENTEX__H3K36me3	2.15182e-08	0.0439383	False
Primary_B_cells_from_peripheral_blood__DNase	2.50098e-08	0.0452112	False
Primary_B_cells_from_peripheral_blood__H3K4me3	5.5938e-08	0.0515071	False
Testis_ENTEX__H3K4me3	2.70746e-08	0.0531257	False
Heart-Atrial_ENTEX__H3K4me3	5.13986e-08	0.0559334	False
Heart-LV_ENTEX__H3K4me1	1.55843e-08	0.0610477	False
Colonic_Mucosa__H3K36me3	2.08864e-08	0.0612603	False
Brain_Cingulate_Gyrus__H3K36me3	1.83111e-08	0.0613562	False
Placenta_Amnion__H3K27ac	2.74568e-08	0.0628666	False
Gastric__H3K36me3	1.81239e-08	0.07073	False
Sigmoid_Colon__H3K36me3	1.9055e-08	0.0710655	False
Fetal_Intestine_Small__H3K36me3	8.81488e-09	0.0714708	False
Fetal_Stomach__H3K36me3	1.09166e-08	0.0736643	False
Ovary__DNase	1.70768e-08	0.0768442	False
Pancreatic_Islets__H3K27ac	3.13705e-08	0.0831924	False
Fetal_Muscle_Trunk__H3K4me1	8.74454e-09	0.084134	False
Spleen_ENTEX__H3K36me3	6.61889e-09	0.0846659	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Female__H3K27ac	1.28869e-08	0.0906127	False
Pancreatic_Islets__H3K9ac	5.28154e-08	0.09084	False
Vagina_ENTEX__H3K4me3	4.21843e-08	0.0918642	False
Brain_Inferior_Temporal_Lobe__H3K36me3	1.46093e-08	0.09499	False
Esoph-Mucosa_ENTEX__H3K4me3	3.16129e-08	0.101219	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Female__DNase	2.41431e-08	0.101233	False
Esoph-GJ_ENTEX__H3K27ac	9.47765e-09	0.101852	False
Stomach_ENTEX__H3K4me3	2.80549e-08	0.102304	False
Primary_B_cells_from_peripheral_blood__H3K36me3	7.25527e-09	0.104358	False
Spleen__H3K36me3	1.09456e-08	0.104431	False
Thymus__H3K36me3	1.66885e-08	0.105572	False
Skeletal_Muscle_Male__H3K9ac	1.42825e-08	0.110907	False
Foreskin_Melanocyte_Primary_Cells_skin01__H3K4me1	1.78417e-08	0.11153	False
Skeletal_Muscle_Male__H3K36me3	1.31223e-08	0.113288	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Male__DNase	2.6125e-08	0.114544	False
Skeletal_Muscle_Female__H3K9ac	1.9202e-08	0.116018	False
Brain_Hippocampus_Middle__H3K36me3	1.19243e-08	0.117558	False
Spleen__H3K4me3	2.13465e-08	0.124035	False
Esoph-Muscularis_ENTEX__H3K4me3	2.83122e-08	0.128362	False
Fetal_Thymus__H3K36me3	6.37548e-09	0.128524	False
Heart-Atrial_ENTEX__H3K36me3	8.34636e-09	0.133442	False
Placenta_Amnion__H3K4me1	9.58957e-09	0.144238	False
Esophagus__H3K36me3	1.29095e-08	0.146963	False
Foreskin_Fibroblast_Primary_Cells_skin02__H3K4me3	1.1557e-08	0.148682	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Male__H3K4me3	2.04601e-08	0.149504	False
Colon-Sigm_ENTEX__H3K27ac	8.62511e-09	0.149542	False
Fetal_Thymus__DNase	1.551e-08	0.15119	False
Vagina_ENTEX__H3K27ac	8.13163e-09	0.152004	False
Stomach_ENTEX__H3K36me3	7.35331e-09	0.156833	False
Spleen_ENTEX__H3K27ac	4.64552e-09	0.159025	False
Primary_B_cells_from_cord_blood__H3K4me1	7.17287e-09	0.159581	False
Skeletal_Muscle_Male__H3K4me1	7.55931e-09	0.163582	False
Pancreatic_Islets__H3K4me1	8.14494e-09	0.164777	False
Cortex_derived_primary_cultured_neurospheres__H3K36me3	9.60224e-09	0.164977	False
Right_Ventricle__H3K4me1	1.02982e-08	0.16631	False
Placenta__H3K36me3	8.44934e-09	0.17351	False
Esoph-Muscularis_ENTEX__H3K27ac	6.86957e-09	0.179814	False
Ganglion_Eminence_derived_primary_cultured_neurospheres__H3K36me3	8.94773e-09	0.184572	False
Fetal_Intestine_Large__H3K36me3	7.06165e-09	0.186759	False
Fetal_Muscle_Trunk__H3K36me3	9.73002e-09	0.191806	False
Colon-Sigm_ENTEX__H3K36me3	9.47401e-09	0.199143	False
Esophagus__H3K4me3	3.75754e-08	0.212616	False
Primary_B_cells_from_peripheral_blood__H3K27ac	7.82643e-09	0.217571	False
Lung_ENTEX__H3K4me1	5.34695e-09	0.220455	False
Skeletal_Muscle_Female__H3K4me1	4.69468e-09	0.228411	False
Ovary__H3K27ac	7.62063e-09	0.228684	False
Brain_Substantia_Nigra__H3K36me3	1.22947e-08	0.229031	False
Fetal_Thymus__H3K4me1	4.30843e-09	0.229721	False
Primary_T_cells_from_cord_blood__DNase	1.45968e-08	0.230408	False
Pancreatic_Islets__H3K4me3	2.742e-08	0.230681	False
Fetal_Adrenal_Gland__DNase	1.26271e-08	0.230923	False
Primary_mononuclear_cells_from_peripheral_blood__H3K4me3	2.62372e-08	0.231609	False
Mammary_ENTEX__H3K4me3	1.38104e-08	0.23578	False
Right_Atrium__H3K36me3	1.07852e-08	0.237728	False
Colon-Sigm_ENTEX__H3K4me3	2.716e-08	0.238907	False
Right_Ventricle__H3K4me3	2.12555e-08	0.242447	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Female__H3K4me1	3.79387e-09	0.262286	False
Primary_T_killer_memory_cells_from_peripheral_blood__H3K27ac	9.20145e-09	0.265306	False
liver_ENTEX__H3K36me3	6.22789e-09	0.265504	False
Primary_B_cells_from_cord_blood__H3K4me3	2.13149e-08	0.266636	False
Right_Ventricle__H3K36me3	6.97409e-09	0.267085	False
Primary_T_cells_from_peripheral_blood__DNase	9.42171e-09	0.278581	False
Primary_mononuclear_cells_from_peripheral_blood__H3K9ac	1.10287e-08	0.28134	False
Pancreas__H3K4me1	5.26709e-09	0.281415	False
Esoph-GJ_ENTEX__H3K4me3	1.28005e-08	0.283422	False
Primary_T_cells_from_cord_blood__H3K4me3	1.54478e-08	0.284556	False
Primary_T_helper_cells_from_peripheral_blood__H3K27ac	6.00066e-09	0.300183	False
Nerve-Tibial_ENTEX__H3K4me1	3.46717e-09	0.307061	False
Fetal_Brain_Male__H3K4me3	2.45645e-08	0.308282	False
Nerve-Tibial_ENTEX__H3K4me3	1.59112e-08	0.311894	False
Foreskin_Fibroblast_Primary_Cells_skin02__H3K27ac	4.92819e-09	0.312645	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Male__H3K4me1	3.06457e-09	0.313794	False
Foreskin_Fibroblast_Primary_Cells_skin02__H3K36me3	3.74064e-09	0.316645	False
Right_Ventricle__H3K27ac	4.66982e-09	0.316698	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Female__H3K4me3	1.25125e-08	0.317218	False
Nerve-Tibial_ENTEX__H3K27ac	2.16714e-09	0.318534	False
Spleen_ENTEX__H3K4me3	4.72344e-09	0.323033	False
Primary_B_cells_from_peripheral_blood__H3K4me1	2.52546e-09	0.323377	False
Primary_Natural_Killer_cells_from_peripheral_blood__H3K4me3	1.31025e-08	0.323724	False
Placenta__H3K27ac	2.95739e-09	0.327236	False
Fetal_Muscle_Trunk__H3K27ac	4.30205e-09	0.336661	False
Primary_T_helper_naive_cells_from_peripheral_blood_1__H3K36me3	4.61697e-09	0.337476	False
Placenta__H3K4me1	3.11786e-09	0.34294	False
Pancreatic_Islets__H3K36me3	7.63928e-09	0.347705	False
Small_Intestine__H3K36me3	9.1946e-09	0.357231	False
Primary_T_helper_memory_cells_from_peripheral_blood_2__H3K36me3	6.32089e-09	0.357804	False
Heart-Atrial_ENTEX__H3K4me1	1.22539e-08	0.35905	False
Stomach_ENTEX__H3K4me1	2.70381e-09	0.35937	False
Primary_B_cells_from_cord_blood__H3K36me3	9.46559e-09	0.360663	False
Primary_hematopoietic_stem_cells__H3K4me3	1.25322e-08	0.364479	False
Skeletal_Muscle_Female__H3K27ac	2.4496e-09	0.364906	False
Foreskin_Keratinocyte_Primary_Cells_skin02__H3K36me3	2.71058e-09	0.367242	False
Primary_T_helper_cells_PMA-I_stimulated__H3K4me1	2.04822e-09	0.36794	False
Colon-TV_ENTEX__H3K36me3	3.87581e-09	0.374834	False
Primary_neutrophils_from_peripheral_blood__H3K4me3	3.82617e-09	0.376483	False
Primary_T_helper_naive_cells_from_peripheral_blood_2__H3K27ac	2.9229e-09	0.377144	False
Foreskin_Melanocyte_Primary_Cells_skin01__H3K4me3	7.46865e-09	0.37815	False
Stomach_Mucosa__H3K36me3	5.62005e-09	0.379591	False
Rectal_Mucosa_Donor_31__H3K36me3	3.04238e-09	0.382096	False
Foreskin_Melanocyte_Primary_Cells_skin01__H3K36me3	4.44019e-09	0.383911	False
Pancreas_ENTEX__H3K36me3	2.37537e-09	0.387769	False
NHLF_Lung_Fibroblast_Primary_Cells__H3K36me3	4.1214e-09	0.388899	False
Primary_monocytes_from_peripheral_blood__H3K4me3	8.60207e-09	0.390475	False
Placenta__DNase	2.8043e-09	0.416837	False
Primary_hematopoietic_stem_cells__H3K4me1	2.69691e-09	0.417681	False
Fetal_Heart__H3K36me3	3.69727e-09	0.421833	False
Primary_T_regulatory_cells_from_peripheral_blood__H3K36me3	1.23588e-09	0.423412	False
Fetal_Muscle_Leg__H3K36me3	1.65261e-09	0.428397	False
Fetal_Heart__DNase	1.68021e-09	0.435854	False
Duodenum_Mucosa__H3K36me3	1.35775e-09	0.437595	False
Primary_mononuclear_cells_from_peripheral_blood__H3K36me3	1.15581e-09	0.438988	False
Ovary__H3K4me3	4.71535e-09	0.439657	False
Right_Atrium__H3K4me3	4.9101e-09	0.440957	False
Primary_T_killer_memory_cells_from_peripheral_blood__H3K36me3	1.90349e-09	0.444025	False
Ovary__H3K4me1	1.30242e-09	0.444138	False
Thyroid_gland_ENTEX__H3K4me3	3.66549e-09	0.444206	False
Skeletal_Muscle_Male__H3K4me3	2.64595e-09	0.447654	False
Lung__H3K36me3	1.42308e-09	0.454045	False
Pancreas__H3K36me3	1.50732e-09	0.454901	False
skeletal_muscle_ENTEX__H3K4me3	8.29313e-10	0.466039	False
Primary_T_cells_from_peripheral_blood__H3K4me1	6.42673e-10	0.468293	False
Primary_T_helper_naive_cells_from_peripheral_blood_2__H3K4me3	1.53354e-09	0.471666	False
Primary_T_helper_naive_cells_from_peripheral_blood_1__H3K4me3	1.50484e-09	0.473452	False
Primary_T_regulatory_cells_from_peripheral_blood__H3K27ac	5.84572e-10	0.474016	False
Heart-LV_ENTEX__H3K36me3	6.12481e-10	0.474175	False
Stomach_ENTEX__H3K27ac	3.86716e-10	0.475512	False
Primary_hematopoietic_stem_cells_short_term_culture__H3K36me3	3.62699e-10	0.477111	False
Breast_Myoepithelial_Primary_Cells__H3K4me3	1.32493e-09	0.478337	False
Primary_T_helper_cells_PMA-I_stimulated__H3K27ac	3.04828e-10	0.48157	False
Primary_T_cells_effector_memory_enriched_from_peripheral_blood__H3K4me1	4.92287e-10	0.481695	False
Primary_T_helper_cells_from_peripheral_blood__H3K4me3	1.03507e-09	0.48348	False
Mammary_ENTEX__H3K27ac	2.54202e-10	0.484477	False
Liver__H3K9ac	5.23509e-10	0.484751	False
Fetal_Adrenal_Gland__H3K4me3	1.34016e-09	0.48697	False
Pancreas_ENTEX__H3K4me1	1.37985e-10	0.487046	False
liver_ENTEX__H3K4me3	4.80507e-10	0.488131	False
Primary_T_helper_naive_cells_from_peripheral_blood_1__H3K4me1	6.95303e-11	0.496542	False
Uterus_ENTEX__H3K4me3	3.18326e-10	0.496613	False
Primary_monocytes_from_peripheral_blood__H3K27ac	1.42198e-11	0.499443	False
Esoph-Mucosa_ENTEX__H3K27ac	-1.411e-10	0.506014	False
Primary_T_helper_cells_from_peripheral_blood__H3K4me1	-1.17324e-10	0.506694	False
Thyroid_gland_ENTEX__H3K27ac	-8.12363e-11	0.507026	False
Psoas_Muscle__H3K4me3	-1.07058e-09	0.511353	False
Primary_T_helper_naive_cells_from_peripheral_blood_2__H3K4me1	-2.69522e-10	0.515468	False
Primary_T_killer_naive_cells_from_peripheral_blood__H3K4me1	-2.90504e-10	0.516192	False
Primary_T_helper_naive_cells_from_peripheral_blood_1__H3K27ac	-1.00598e-09	0.522881	False
Adrenal_gland_ENTEX__H3K27ac	-3.19252e-10	0.526482	False
Esoph-GJ_ENTEX__H3K4me1	-5.46906e-10	0.52934	False
Foreskin_Fibroblast_Primary_Cells_skin02__DNase	-1.344e-09	0.529817	False
Primary_hematopoietic_stem_cells_short_term_culture__H3K4me3	-2.27559e-09	0.531886	False
Small_Intestine__H3K4me3	-3.02638e-09	0.532666	False
Primary_mononuclear_cells_from_peripheral_blood__H3K27ac	-2.23075e-09	0.537416	False
Primary_T_killer_memory_cells_from_peripheral_blood__H3K4me1	-8.10898e-10	0.53749	False
Skeletal_Muscle_Female__H3K36me3	-8.04332e-10	0.545059	False
Primary_neutrophils_from_peripheral_blood__H3K4me1	-6.06484e-10	0.549542	False
Rectal_Mucosa_Donor_29__H3K36me3	-1.4134e-09	0.554111	False
Fetal_Muscle_Leg__H3K4me3	-5.82614e-09	0.562408	False
Fetal_Kidney__DNase	-2.64811e-09	0.565275	False
Foreskin_Fibroblast_Primary_Cells_skin01__H3K36me3	-1.02044e-09	0.566027	False
Primary_Natural_Killer_cells_from_peripheral_blood__H3K36me3	-1.26932e-09	0.566405	False
Adipose_Nuclei__H3K27ac	-9.40338e-10	0.568287	False
Artery-Coronary_ENTEX__H3K4me3	-2.28902e-09	0.570099	False
Primary_T_cells_from_cord_blood__H3K4me1	-2.3726e-09	0.570788	False
Liver__H3K4me1	-1.13482e-09	0.573408	False
Fetal_Muscle_Leg__H3K4me1	-1.34041e-09	0.574898	False
Heart-LV_ENTEX__H3K27ac	-1.14758e-09	0.575019	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Female__H3K36me3	-1.37194e-09	0.581374	False
Psoas_Muscle__H3K4me1	-2.40144e-09	0.582839	False
Placenta__H3K4me3	-1.18287e-08	0.590377	False
Primary_T_cells_effector_memory_enriched_from_peripheral_blood__H3K27ac	-2.38958e-09	0.590419	False
Thyroid_gland_ENTEX__H3K36me3	-1.85565e-09	0.591364	False
Lung_ENTEX__H3K27ac	-1.43546e-09	0.593466	False
Primary_T_cells_from_peripheral_blood__H3K4me3	-6.81122e-09	0.604137	False
Uterus_ENTEX__H3K27ac	-1.47116e-09	0.604474	False
Esoph-Muscularis_ENTEX__H3K36me3	-2.25446e-09	0.612212	False
Adipose_Nuclei__H3K4me1	-1.99198e-09	0.615353	False
Left_Ventricle__H3K27ac	-2.44567e-09	0.6204	False
Thyroid_gland_ENTEX__H3K4me1	-1.76301e-09	0.628978	False
Primary_T_helper_17_cells_PMA-I_stimulated__H3K36me3	-2.89389e-09	0.629072	False
Primary_T_regulatory_cells_from_peripheral_blood__H3K4me1	-2.98506e-09	0.632181	False
Primary_T_cells_from_peripheral_blood__H3K27ac	-3.38314e-09	0.632457	False
Primary_T_helper_memory_cells_from_peripheral_blood_2__H3K4me1	-2.29751e-09	0.634265	False
Primary_T_cells_from_peripheral_blood__H3K36me3	-2.67488e-09	0.640697	False
Foreskin_Keratinocyte_Primary_Cells_skin03__H3K36me3	-1.58756e-09	0.641005	False
Spleen__H3K27ac	-3.62866e-09	0.648965	False
Pancreas_ENTEX__H3K27ac	-1.98131e-09	0.653433	False
Foreskin_Melanocyte_Primary_Cells_skin03__H3K4me1	-2.17684e-09	0.655227	False
Primary_T_helper_cells_PMA-I_stimulated__H3K4me3	-5.94916e-09	0.657231	False
Prostate_ENTEX__H3K4me3	-1.46788e-08	0.657689	False
Primary_T_helper_cells_from_peripheral_blood__H3K36me3	-2.37831e-09	0.659755	False
skeletal_muscle_ENTEX__H3K36me3	-2.25951e-09	0.661155	False
Foreskin_Melanocyte_Primary_Cells_skin03__H3K27ac	-3.75905e-09	0.665063	False
Foreskin_Melanocyte_Primary_Cells_skin01__DNase	-5.36404e-09	0.66801	False
Mammary_ENTEX__H3K4me1	-6.94869e-09	0.669675	False
Primary_T_helper_memory_cells_from_peripheral_blood_1__H3K4me1	-3.00624e-09	0.66986	False
Left_Ventricle__H3K4me1	-4.75752e-09	0.670565	False
Primary_hematopoietic_stem_cells_G-CSF-mobilized_Male__H3K36me3	-2.75968e-09	0.671839	False
Breast_Myoepithelial_Primary_Cells__H3K36me3	-3.58039e-09	0.672348	False
Fetal_Muscle_Trunk__DNase	-6.85609e-09	0.676843	False
Primary_T_helper_naive_cells_from_peripheral_blood_2__H3K36me3	-3.79946e-09	0.678601	False
Primary_T_helper_memory_cells_from_peripheral_blood_2__H3K27ac	-5.58011e-09	0.681792	False
Fetal_Lung__H3K4me3	-1.29889e-08	0.682751	False
Liver__H3K36me3	-2.82634e-09	0.68433	False
Foreskin_Fibroblast_Primary_Cells_skin01__DNase	-8.52518e-09	0.686117	False
Fetal_Heart__H3K4me1	-2.49628e-09	0.687172	False
Gastric__DNase	-1.29838e-08	0.688397	False
Foreskin_Melanocyte_Primary_Cells_skin03__H3K4me3	-1.33752e-08	0.688738	False
Primary_T_killer_memory_cells_from_peripheral_blood__H3K4me3	-1.23337e-08	0.690025	False
NHEK-Epidermal_Keratinocyte_Primary_Cells__H3K4me3	-1.13174e-08	0.695403	False
Primary_T_helper_cells_PMA-I_stimulated__H3K36me3	-3.41148e-09	0.697737	False
Ovary_ENTEX__H3K36me3	-2.13684e-08	0.702298	False
Fetal_Stomach__H3K27ac	-5.63261e-09	0.708894	False
Fetal_Adrenal_Gland__H3K36me3	-4.32388e-09	0.71452	False
Thymus__H3K4me1	-5.94359e-09	0.71987	False
Gastric__H3K4me1	-7.69441e-09	0.720879	False
Sigmoid_Colon__H3K4me3	-2.23636e-08	0.721976	False
Breast_Myoepithelial_Primary_Cells__H3K9ac	-1.36608e-08	0.725088	False
Primary_monocytes_from_peripheral_blood__DNase	-1.11912e-08	0.727894	False
Testis_ENTEX__H3K27ac	-3.30888e-09	0.728394	False
Fetal_Intestine_Large__DNase	-9.81309e-09	0.729723	False
Primary_T_cells_effector_memory_enriched_from_peripheral_blood__H3K4me3	-1.56111e-08	0.73056	False
Liver__H3K27ac	-3.98834e-09	0.73622	False
Primary_mononuclear_cells_from_peripheral_blood__H3K4me1	-1.5515e-08	0.737588	False
Primary_T_helper_memory_cells_from_peripheral_blood_1__H3K4me3	-1.36664e-08	0.739631	False
Primary_T_helper_memory_cells_from_peripheral_blood_2__H3K4me3	-1.61459e-08	0.741293	False
Primary_T_killer_naive_cells_from_peripheral_blood__H3K27ac	-1.0334e-08	0.741294	False
liver_ENTEX__H3K27ac	-3.47839e-09	0.742615	False
Primary_T_helper_memory_cells_from_peripheral_blood_1__H3K27ac	-7.83511e-09	0.746241	False
Spleen_ENTEX__H3K4me1	-1.19202e-08	0.749779	False
Skeletal_Muscle_Female__H3K4me3	-1.1853e-08	0.750142	False
Fetal_Thymus__H3K27ac	-6.09562e-09	0.750283	False
NHEK-Epidermal_Keratinocyte_Primary_Cells__H3K27ac	-6.58479e-09	0.750921	False
NHEK-Epidermal_Keratinocyte_Primary_Cells__H3K9ac	-9.887e-09	0.751319	False
Primary_T_helper_17_cells_PMA-I_stimulated__H3K27ac	-7.67703e-09	0.75224	False
Primary_T_cells_effector_memory_enriched_from_peripheral_blood__H3K36me3	-6.51201e-09	0.755282	False
Foreskin_Keratinocyte_Primary_Cells_skin03__H3K4me3	-1.55952e-08	0.75534	False
Foreskin_Fibroblast_Primary_Cells_skin02__H3K4me1	-4.76934e-09	0.759342	False
Fetal_Stomach__DNase	-1.48189e-08	0.76043	False
Fetal_Stomach__H3K4me3	-3.1756e-08	0.761965	False
Primary_Natural_Killer_cells_from_peripheral_blood__H3K4me1	-4.92272e-09	0.766056	False
Duodenum_Mucosa__H3K4me3	-1.50051e-08	0.767299	False
Thymus__H3K4me3	-2.29786e-08	0.767664	False
Adrenal_gland_ENTEX__H3K4me1	-5.05449e-09	0.771805	False
Primary_T_killer_naive_cells_from_peripheral_blood__H3K9ac	-2.02561e-08	0.771949	False
Primary_monocytes_from_peripheral_blood__H3K4me1	-4.50611e-09	0.773561	False
Foreskin_Fibroblast_Primary_Cells_skin01__H3K27ac	-7.30837e-09	0.774045	False
Primary_T_regulatory_cells_from_peripheral_blood__H3K4me3	-1.41307e-08	0.775338	False
Primary_hematopoietic_stem_cells__H3K36me3	-1.15203e-08	0.779934	False
Gastric__H3K27ac	-1.16095e-08	0.784345	False
Primary_T_helper_17_cells_PMA-I_stimulated__H3K4me3	-1.47468e-08	0.794944	False
Primary_monocytes_from_peripheral_blood__H3K36me3	-4.72957e-09	0.799963	False
Foreskin_Keratinocyte_Primary_Cells_skin02__H3K4me3	-2.32134e-08	0.801223	False
Primary_T_cells_from_cord_blood__H3K36me3	-1.13896e-08	0.806466	False
Fetal_Muscle_Trunk__H3K4me3	-3.24269e-08	0.806791	False
Thymus__H3K27ac	-1.45241e-08	0.810675	False
Primary_T_helper_naive_cells_from_peripheral_blood__H3K9ac	-2.03767e-08	0.813032	False
Lung__H3K4me1	-1.10673e-08	0.814675	False
Primary_T_helper_17_cells_PMA-I_stimulated__H3K4me1	-6.56055e-09	0.815275	False
Adipose_Nuclei__H3K9ac	-1.50756e-08	0.815855	False
Primary_T_killer_naive_cells_from_peripheral_blood__H3K36me3	-1.0804e-08	0.816115	False
Fetal_Muscle_Leg__H3K27ac	-8.22074e-09	0.828535	False
Primary_Natural_Killer_cells_from_peripheral_blood__DNase	-1.64181e-08	0.830794	False
Foreskin_Keratinocyte_Primary_Cells_skin03__H3K27ac	-9.47988e-09	0.83536	False
Ovary_ENTEX__H3K4me3	-3.26181e-08	0.837425	False
Left_Ventricle__H3K4me3	-4.04302e-08	0.839276	False
Fetal_Thymus__H3K4me3	-2.75691e-08	0.844554	False
Fetal_Intestine_Small__DNase	-2.08726e-08	0.846162	False
Primary_T_helper_memory_cells_from_peripheral_blood_1__H3K36me3	-1.16801e-08	0.84714	False
Esoph-Mucosa_ENTEX__H3K4me1	-7.71151e-09	0.847958	False
Fetal_Stomach__H3K4me1	-7.10615e-09	0.849372	False
Artery-Tibial_ENTEX__H3K36me3	-8.49306e-09	0.856828	False
Fetal_Adrenal_Gland__H3K4me1	-7.07124e-09	0.856917	False
Colon-Sigm_ENTEX__H3K4me1	-5.12507e-08	0.860592	False
Pancreas__H3K27ac	-1.67722e-08	0.860839	False
NHLF_Lung_Fibroblast_Primary_Cells__DNase	-1.83545e-08	0.862785	False
Prostate_ENTEX__H3K36me3	-7.50857e-08	0.864773	False
SI-Term-Ileum_ENTEX__H3K4me3	-2.05249e-08	0.871027	False
liver_ENTEX__H3K4me1	-2.89496e-08	0.871091	False
Right_Atrium__H3K4me1	-1.47978e-08	0.872137	False
Fetal_Intestine_Large__H3K4me3	-3.49286e-08	0.8725	False
NHDF-Ad_Adult_Dermal_Fibroblast_Primary_Cells__H3K4me1	-1.09115e-08	0.872709	False
Primary_hematopoietic_stem_cells_short_term_culture__H3K4me1	-8.954e-09	0.873424	False
Fetal_Lung__H3K9ac	-2.72263e-08	0.878649	False
Small_Intestine__DNase	-1.81459e-08	0.87973	False
Stomach_Smooth_Muscle__H3K4me3	-2.03912e-08	0.879769	False
Fetal_Intestine_Small__H3K4me1	-8.01267e-09	0.88418	False
Fetal_Adrenal_Gland__H3K27ac	-7.82747e-09	0.884424	False
NHEK-Epidermal_Keratinocyte_Primary_Cells__DNase	-1.4554e-08	0.887288	False
Foreskin_Fibroblast_Primary_Cells_skin01__H3K4me3	-1.92389e-08	0.88856	False
Fetal_Brain_Male__H3K36me3	-3.83798e-08	0.890449	False
Duodenum_Smooth_Muscle__H3K4me1	-1.47083e-08	0.892111	False
Lung_ENTEX__H3K36me3	-8.92732e-09	0.893488	False
Vagina_ENTEX__H3K36me3	-3.35326e-08	0.894054	False
HMEC_Mammary_Epithelial_Primary_Cells__H3K27ac	-1.28129e-08	0.894238	False
Stomach_Smooth_Muscle__H3K9ac	-2.72529e-08	0.894909	False
Primary_neutrophils_from_peripheral_blood__H3K36me3	-6.20832e-09	0.896184	False
HMEC_Mammary_Epithelial_Primary_Cells__H3K4me3	-3.89006e-08	0.897184	False
NHEK-Epidermal_Keratinocyte_Primary_Cells__H3K4me1	-9.81336e-09	0.898985	False
Fetal_Intestine_Large__H3K4me1	-8.83809e-09	0.901499	False
Rectal_Smooth_Muscle__H3K9ac	-4.01416e-08	0.902191	False
Pancreas__H3K4me3	-3.60635e-08	0.906806	False
Aorta__H3K4me3	-4.17828e-08	0.906813	False
Right_Atrium__H3K27ac	-1.54965e-08	0.908018	False
Colon_Smooth_Muscle__H3K9ac	-2.76778e-08	0.908075	False
NHEK-Epidermal_Keratinocyte_Primary_Cells__H3K36me3	-9.42891e-09	0.909284	False
Ovary__H3K36me3	-1.4415e-08	0.909741	False
Nerve-Tibial_ENTEX__H3K36me3	-1.11656e-08	0.911448	False
Fetal_Muscle_Leg__DNase	-1.77895e-08	0.914128	False
SI-Term-Ileum_ENTEX__H3K27ac	-9.18182e-09	0.915666	False
NHLF_Lung_Fibroblast_Primary_Cells__H3K4me1	-1.6698e-08	0.91684	False
Fetal_Intestine_Small__H3K4me3	-4.55659e-08	0.917257	False
Fetal_Heart__H3K9ac	-1.33984e-08	0.919192	False
Colon-TV_ENTEX__H3K4me1	-2.8098e-08	0.921088	False
SI-Term-Ileum_ENTEX__H3K36me3	-3.27279e-08	0.922133	False
Breast_Myoepithelial_Primary_Cells__H3K4me1	-7.7581e-09	0.92226	False
Lung_ENTEX__H3K4me3	-5.06721e-08	0.923398	False
Adrenal_gland_ENTEX__H3K36me3	-1.21616e-08	0.926611	False
Psoas_Muscle__H3K36me3	-2.61255e-08	0.928423	False
Primary_Natural_Killer_cells_from_peripheral_blood__H3K27ac	-1.30681e-08	0.929183	False
Colonic_Mucosa__H3K4me1	-2e-08	0.929395	False
Fetal_Intestine_Large__H3K27ac	-1.08763e-08	0.929471	False
Stomach_Smooth_Muscle__H3K4me1	-1.17542e-08	0.929772	False
Fetal_Kidney__H3K36me3	-3.213e-08	0.930345	False
Liver__H3K4me3	-1.80775e-08	0.932865	False
Foreskin_Keratinocyte_Primary_Cells_skin02__H3K4me1	-1.66952e-08	0.934855	False
Esophagus__H3K4me1	-2.1317e-08	0.935974	False
Fetal_Lung__H3K36me3	-1.26239e-08	0.938334	False
HMEC_Mammary_Epithelial_Primary_Cells__H3K4me1	-1.37669e-08	0.938568	False
Sigmoid_Colon__H3K4me1	-3.0747e-08	0.941893	False
Artery-Tibial_ENTEX__H3K4me1	-3.12492e-08	0.942183	False
Placenta_Amnion__H3K4me3	-5.71598e-08	0.945137	False
Aorta_ENTEX__H3K36me3	-9.06273e-09	0.945351	False
Foreskin_Fibroblast_Primary_Cells_skin01__H3K4me1	-1.01456e-08	0.946612	False
HMEC_Mammary_Epithelial_Primary_Cells__H3K9ac	-2.72716e-08	0.947905	False
Foreskin_Keratinocyte_Primary_Cells_skin02__DNase	-2.15741e-08	0.948636	False
Artery-Coronary_ENTEX__H3K27ac	-1.0105e-08	0.948986	False
Colon_Smooth_Muscle__H3K36me3	-1.72891e-08	0.949255	False
Foreskin_Keratinocyte_Primary_Cells_skin03__H3K4me1	-1.23705e-08	0.949525	False
Colon_Smooth_Muscle__H3K27ac	-1.34244e-08	0.952071	False
Pancreas__DNase	-3.32528e-08	0.955974	False
Lung__H3K27ac	-1.867e-08	0.956541	False
Stomach_Smooth_Muscle__H3K27ac	-1.11381e-08	0.958312	False
Pancreas_ENTEX__H3K4me3	-4.06297e-08	0.959498	False
Primary_T_killer_naive_cells_from_peripheral_blood__H3K4me3	-4.38198e-08	0.959578	False
Fetal_Heart__H3K4me3	-2.6645e-08	0.960671	False
NHDF-Ad_Adult_Dermal_Fibroblast_Primary_Cells__H3K9ac	-4.3553e-08	0.960853	False
Fetal_Kidney__H3K4me3	-7.17413e-08	0.961516	False
Testis_ENTEX__H3K36me3	-8.13763e-08	0.961925	False
Foreskin_Melanocyte_Primary_Cells_skin03__H3K36me3	-8.85115e-09	0.963619	False
Duodenum_Smooth_Muscle__H3K4me3	-2.25781e-08	0.964743	False
Aorta_ENTEX__H3K4me3	-1.95095e-08	0.965138	False
Fetal_Kidney__H3K4me1	-3.34743e-08	0.966382	False
Lung__H3K4me3	-6.9615e-08	0.966919	False
Adipose_Nuclei__H3K36me3	-1.6148e-08	0.968793	False
NHDF-Ad_Adult_Dermal_Fibroblast_Primary_Cells__H3K27ac	-2.40995e-08	0.969196	False
Adrenal_gland_ENTEX__H3K4me3	-3.72807e-08	0.969877	False
NHLF_Lung_Fibroblast_Primary_Cells__H3K27ac	-2.25809e-08	0.970281	False
Skin_tissue_ENTEX__H3K4me3	-5.43347e-08	0.970642	False
NHDF-Ad_Adult_Dermal_Fibroblast_Primary_Cells__DNase	-3.18941e-08	0.971035	False
Prostate_ENTEX__H3K27ac	-1.35335e-08	0.97239	False
Fetal_Intestine_Small__H3K27ac	-1.48746e-08	0.974041	False
HMEC_Mammary_Epithelial_Primary_Cells__H3K36me3	-1.96334e-08	0.974167	False
Adipose_Nuclei__H3K4me3	-2.89469e-08	0.974371	False
Rectal_Smooth_Muscle__H3K27ac	-1.56012e-08	0.977844	False
Colonic_Mucosa__H3K4me3	-5.38827e-08	0.978568	False
Fetal_Lung__H3K4me1	-1.42964e-08	0.979037	False
NHDF-Ad_Adult_Dermal_Fibroblast_Primary_Cells__H3K36me3	-3.6937e-08	0.979066	False
NHLF_Lung_Fibroblast_Primary_Cells__H3K9ac	-5.39667e-08	0.979366	False
Breast_variant_Human_Mammary_Epithelial_Cells_(vHMEC)__H3K36me3	-1.14342e-08	0.981128	False
Rectal_Mucosa_Donor_29__H3K4me1	-2.56948e-08	0.981623	False
Esophagus__H3K27ac	-2.30141e-08	0.981754	False
Aorta_ENTEX__H3K27ac	-8.16246e-09	0.981832	False
SI-Term-Ileum_ENTEX__H3K4me1	-2.34541e-08	0.98315	False
Breast_variant_Human_Mammary_Epithelial_Cells_(vHMEC)__DNase	-3.28408e-08	0.98339	False
Osteoblast_Primary_Cells__H3K4me3	-4.83673e-08	0.983783	False
Stomach_Smooth_Muscle__H3K36me3	-2.21949e-08	0.983805	False
Rectal_Mucosa_Donor_31__H3K4me3	-4.81441e-08	0.984764	False
Colon-TV_ENTEX__H3K4me3	-6.59617e-08	0.985574	False
Colon-TV_ENTEX__H3K27ac	-1.31267e-08	0.98688	False
Left_Ventricle__H3K36me3	-2.34619e-08	0.987129	False
Breast_variant_Human_Mammary_Epithelial_Cells_(vHMEC)__H3K4me1	-1.81311e-08	0.988535	False
Fetal_Lung__DNase	-3.07985e-08	0.989794	False
Osteoblast_Primary_Cells__H3K4me1	-1.61863e-08	0.990541	False
Rectal_Smooth_Muscle__H3K36me3	-3.77944e-08	0.99064	False
Duodenum_Mucosa__H3K4me1	-2.09439e-08	0.991114	False
Rectal_Smooth_Muscle__H3K4me1	-2.43244e-08	0.991855	False
Rectal_Mucosa_Donor_29__H3K27ac	-2.38222e-08	0.99206	False
Breast_variant_Human_Mammary_Epithelial_Cells_(vHMEC)__H3K4me3	-7.72097e-08	0.992173	False
HMEC_Mammary_Epithelial_Primary_Cells__DNase	-3.72033e-08	0.99564	False
Osteoblast_Primary_Cells__H3K36me3	-1.5335e-08	0.996344	False
Rectal_Mucosa_Donor_31__H3K27ac	-2.65056e-08	0.996582	False
Rectal_Mucosa_Donor_31__H3K4me1	-2.42821e-08	0.996622	False
Colonic_Mucosa__H3K27ac	-3.16029e-08	0.997112	False
Aorta_ENTEX__H3K4me1	-1.12649e-08	0.997481	False
Aorta__H3K27ac	-2.38166e-08	0.997566	False
Rectal_Mucosa_Donor_29__H3K4me3	-5.44396e-08	0.998137	False
Colon_Smooth_Muscle__H3K4me1	-2.00071e-08	0.998145	False
NHDF-Ad_Adult_Dermal_Fibroblast_Primary_Cells__H3K4me3	-8.93001e-08	0.998467	False
Osteoblast_Primary_Cells__H3K27ac	-2.07313e-08	0.998729	False
Duodenum_Mucosa__H3K9ac	-5.38152e-08	0.998729	False
Duodenum_Smooth_Muscle__H3K27ac	-3.90324e-08	0.999325	False
Colonic_Mucosa__H3K9ac	-6.67811e-08	0.999337	False
Small_Intestine__H3K4me1	-4.3808e-08	0.999424	False
Aorta__H3K4me1	-6.00371e-08	0.999487	False
Colon_Smooth_Muscle__H3K4me3	-7.07213e-08	0.999556	False
NHLF_Lung_Fibroblast_Primary_Cells__H3K4me3	-1.18972e-07	0.999593	False
Rectal_Mucosa_Donor_31__H3K9ac	-5.17013e-08	0.999636	False
Stomach_Mucosa__H3K4me3	-9.37012e-08	0.999645	False
Aorta__H3K36me3	-8.22735e-08	0.999773	False
Fetal_Kidney__H3K9ac	-1.1464e-07	0.999817	False
Small_Intestine__H3K27ac	-4.32544e-08	0.999861	False
Sigmoid_Colon__H3K27ac	-4.05719e-08	0.999892	False
Stomach_Mucosa__H3K4me1	-2.15747e-08	0.999917	False
Duodenum_Smooth_Muscle__H3K36me3	-3.77288e-08	0.99992	False
Stomach_Mucosa__H3K9ac	-5.79856e-08	0.999935	False
Rectal_Mucosa_Donor_29__H3K9ac	-8.20838e-08	0.999949	False
Rectal_Smooth_Muscle__H3K4me3	-1.03416e-07	0.999963	False

Again, the strongest associations are with CNS cell-types.

ImmGen data

Next, I applied S-LDSC using the ImmGen project reference dataset.

There were no significant cell types.

The full results are in the expandable table below.

ImmGen — full results

Name	Coefficient	Coefficient_P_value	Reject Null
DC.8-4-11b+.MLN	2.98736e-09	0.00462889	False
T.4.Pa.BDC	2.59283e-09	0.00577379	False
T.8Mem.LN	2.84682e-09	0.00747125	False
DC.8-4-11b-.SLN	2.66736e-09	0.0112405	False
preT.DN2-3.Th	2.40178e-09	0.0119642	False
T.4int8+.Th	2.52604e-09	0.013297	False
LN.TR.14w.B6	2.52211e-09	0.0135422	False
preT.ETP-2A.Th	2.49981e-09	0.018837	False
MF.103-11b+.Lu	2.36233e-09	0.0203045	False
MF.Microglia.CNS	2.40239e-09	0.0231643	False
B.Mem.Sp.v2	2.06631e-09	0.0253525	False
Tgd.vg5-.act.IEL	2.08078e-09	0.0331096	False
B.MZ.Sp	2.08586e-09	0.0352896	False
T.8Eff.Sp.OT1.d15.LisOva	1.79257e-09	0.0392425	False
T.4SP69+.Th	1.90948e-09	0.0407805	False
Mo.Lu	1.90425e-09	0.0448848	False
B1a.PC	1.96274e-09	0.0449917	False
Tgd.vg5+.IEL	1.87708e-09	0.0464599	False
Mo.6+2+.BL	1.86916e-09	0.0474178	False
T.DPsm.Th	2.0245e-09	0.0476397	False
T.4Mem.Sp	1.82846e-09	0.0485663	False
T.4Nve.Sp	1.73911e-09	0.0487246	False
DC.8-4-11b+.SLN	1.84359e-09	0.049678	False
DC.8-4-11b-.MLN	1.78096e-09	0.0510515	False
B1a.Sp	1.93227e-09	0.0540105	False
CD8.5h.LN	2.17374e-09	0.0545765	False
DC.8+.Sp.ST	1.71526e-09	0.0547014	False
T.4+8int.Th	1.87848e-09	0.0549579	False
MF.RP.Sp	1.71595e-09	0.0552149	False
DC.8-4-11b+.Sp	1.89153e-09	0.057823	False
T.8Mem.Sp	1.64133e-09	0.0603455	False
GN.Thio.PC	1.83271e-09	0.0621967	False
preT.DN3A.Th	1.64594e-09	0.0628402	False
Tgd.vg2+.Sp.TCRbko	1.7137e-09	0.0632532	False
MF.480hi.LV.Naive	1.48124e-09	0.0668182	False
B.Fo.LN	1.65036e-09	0.0695751	False
T.4SP24-.Th	1.69177e-09	0.0696318	False
DC.IIhilang-103-11blo.SLN	1.81933e-09	0.0708536	False
T.4Mem44h62l.LN	1.6109e-09	0.0711173	False
Tgd.vg5-.IEL	1.81664e-09	0.0715573	False
DC.pDC.8+.MLN	1.64e-09	0.0761776	False
CD4Control	1.39478e-09	0.0774394	False
Tgd.Sp	1.54937e-09	0.0785738	False
T.4FP3+25+.Sp	1.601e-09	0.0792467	False
DC.pDC.8+.SLN	1.61044e-09	0.0826547	False
T.8SP24int.Th	1.58689e-09	0.0826705	False
T.4Nve44-49d-11a-.Sp	1.52458e-09	0.0842916	False
B.T1.Sp	1.49411e-09	0.0868154	False
B1b.PC	1.61483e-09	0.0868607	False
T.8Eff.Sp.OT1.d8.VSVOva	1.33609e-09	0.0921953	False
CD19Control	1.35411e-09	0.0926086	False
Mo.6C-IIint.Bl	1.59298e-09	0.0930649	False
Mo.6C+II+.Bl	1.36805e-09	0.0966632	False
DC.4+.MLN	1.33673e-09	0.0970881	False
Mo.6+2+.SLN	1.39318e-09	0.097448	False
DC.103-11b+F4_80lo.Kd	1.57898e-09	0.0975934	False
B.T2.Sp	1.43428e-09	0.0999076	False
DC.4+.Sp.ST	1.30793e-09	0.101737	False
T.8Mem.Sp.OT1.d100.LisOva	1.28885e-09	0.109	False
NKT.44+NK1.1+.Th	1.37991e-09	0.109332	False
NKT.4-.Lv	1.5234e-09	0.109774	False
T.8Nve.MLN	1.20637e-09	0.110401	False
DC.IIhilang+103+11blo.SLN	1.47174e-09	0.116376	False
CD4.24h.LN	1.25226e-09	0.120331	False
Tgd.vg2+24ahi.e17.Th.v2	1.41692e-09	0.122991	False
B.Fo.PC	1.1217e-09	0.12407	False
DC.IIhilang-103-11b+.SLN	1.36529e-09	0.125884	False
B.Fo.MLN	1.09411e-09	0.126419	False
NK.49CI+.Sp	1.21825e-09	0.128857	False
T.8Mem.Sp.OT1.d45.VSVOva	1.33756e-09	0.128921	False
NKT.4-.Sp	1.19752e-09	0.129849	False
MF.11c-11b+.Lu	1.12649e-09	0.130401	False
Tgd.vg2+24ahi.Th	1.22815e-09	0.132518	False
CD4.5h.LN	1.17953e-09	0.142766	False
DC.11b-.AT.v2	1.11638e-09	0.144112	False
DC.103-11b+24+.Lu	1.13738e-09	0.145688	False
T.DP.Th	1.2411e-09	0.146086	False
preT.DN3-4.Th	1.18721e-09	0.147424	False
B.FrE.BM	1.07924e-09	0.154047	False
T.8SP24-.Th	1.06535e-09	0.157836	False
CD8.CTR.LN	1.15253e-09	0.16333	False
T.8Nve.LN	1.07766e-09	0.166696	False
Tgd.vg2-.Sp	1.05845e-09	0.16682	False
B.T3.Sp	9.52853e-10	0.169368	False
MF.103-11b+.SI	1.09462e-09	0.172463	False
T.8Nve.Sp	1.10672e-09	0.174782	False
T.8Nve.Sp.OT1	1.0379e-09	0.175836	False
NK.Sp	1.06872e-09	0.176045	False
NK.b2m-.Sp	9.58048e-10	0.178932	False
MF.169+11chi.SLN	1.01148e-09	0.179323	False
CD4.CTR.LN	9.41518e-10	0.182593	False
T.DP69+.Th	9.3511e-10	0.183368	False
B.Fo.Sp	8.48021e-10	0.191603	False
DC.8+.MLN	9.19876e-10	0.194359	False
Tgd.vg2+.Sp	8.57228e-10	0.202815	False
NKT.4+.Lv	9.1106e-10	0.203342	False
Tgd.vg4+24ahi.e17.Th	9.79221e-10	0.203959	False
preT.ETP.Th	9.37386e-10	0.204271	False
Mo.6C-II-.Bl	9.6854e-10	0.205375	False
T.8Eff.Sp.OT1.12hr.LisOva	8.36497e-10	0.210392	False
DC.pDC.8+.Sp	9.04906e-10	0.211581	False
T.8Nve.PP	8.70944e-10	0.212386	False
NKT.4+.Sp	9.62939e-10	0.212747	False
Mo.6C+II-.LN	8.96927e-10	0.21365	False
Mo.6+2-.BL	8.29154e-10	0.216813	False
DC.pDC.8-.Sp	8.76765e-10	0.218098	False
Mo.6+2+.MLN	7.86978e-10	0.221481	False
T.4Mem44h62l.Sp	7.47047e-10	0.22969	False
DC.IIhilang+103-11b+.SLN	8.33664e-10	0.231832	False
Tgd.vg5+.act.IEL	8.32311e-10	0.236724	False
MF.11cloSer.Salm3.SI	7.9422e-10	0.237145	False
T.4Mem.LN	7.1775e-10	0.238582	False
T.8Eff.Sp.OT1.d10.LisOva	7.98889e-10	0.244456	False
MF.480int.LV.Naive	6.22958e-10	0.249571	False
GN.UrAc.PC	7.55453e-10	0.250108	False
T.DPbl.Th	6.77292e-10	0.251666	False
T.ISP.Th	7.06705e-10	0.254053	False
NKT.44-NK1.1-.Th	7.11064e-10	0.257506	False
DC.8+.Th	7.08705e-10	0.258199	False
Tgd.vg2-.act.Sp	7.59854e-10	0.261091	False
DC.8+.SLN	6.8199e-10	0.261869	False
B.FrF.BM	6.60072e-10	0.263065	False
Tgd.vg1+vd6-24alo.Th	7.18583e-10	0.263415	False
T.4SP24int.Th	7.32942e-10	0.265357	False
MF.11cloSer.SI	6.31378e-10	0.275777	False
preT.DN2.Th	6.16757e-10	0.277572	False
NK.MCMV1.Sp	5.93581e-10	0.286914	False
preB.FrD.FL	5.24602e-10	0.290053	False
Mo.6C+II-.Bl	5.83817e-10	0.291806	False
T.4Nve.MLN	5.70334e-10	0.300198	False
T.8Eff.Tbet-.Sp.OT1.d6LisOVA	7.20641e-10	0.302912	False
B.GC.Sp	5.16488e-10	0.307516	False
T.8Eff.Sp.OT1.d6.VSVOva	5.50418e-10	0.307935	False
Tgd.vg2+24alo.Th	4.88757e-10	0.310364	False
T.DP.Th.v2	5.69321e-10	0.311171	False
T.4.LN.BDC	5.46642e-10	0.312676	False
T.DP69+.Th.v2	5.08309e-10	0.336433	False
ABD.TR.14w.B6	4.54694e-10	0.341616	False
MF.II+480lo.PC	4.53329e-10	0.348002	False
Mo.6C-II-.BM	4.34258e-10	0.34898	False
NK.H+.MCMV1.Sp	4.00337e-10	0.350821	False
GN.Arth.SynF	4.05799e-10	0.351795	False
T.8Eff.Sp.OT1.d15.VSVOva	3.84345e-10	0.353542	False
T.4Nve.LN	3.77178e-10	0.360212	False
T.8MemKLRG1-CD127+.Sp.d8.LisOVA	3.77402e-10	0.362301	False
preT.DN3B.Th	3.768e-10	0.363555	False
CD8.48h.LN	4.17901e-10	0.364625	False
B.FrE.FL	3.77066e-10	0.366899	False
MF.103-11b+.Salm3.SI	3.3363e-10	0.378914	False
DC.4+.SLN	3.23832e-10	0.380118	False
CD8.1h.LN	3.43164e-10	0.380827	False
MF.Sbcaps.SLN	3.37803e-10	0.383269	False
T.8Mem.Sp.OT1.d45.LisOva	3.04863e-10	0.389156	False
CD4.48h.LN	3.33661e-10	0.3907	False
ILC1.CD127+.Sp	3.01045e-10	0.398938	False
NK.H+.MCMV7.Sp	2.64536e-10	0.399133	False
proB.CLP.BM	2.63041e-10	0.400199	False
preT.DN2B.Th	2.36109e-10	0.403298	False
DC.103+11b-.Lv	2.76048e-10	0.403492	False
MEChi.GFP+.Adult.KO	2.05544e-10	0.414106	False
CD8.24h.LN	2.147e-10	0.417995	False
proB.FrBC.BM	2.16468e-10	0.419097	False
MF.BM	2.39721e-10	0.425588	False
NK.49CI-.Sp	1.96399e-10	0.42764	False
Tgd.vg2+.act.Sp	1.35603e-10	0.449123	False
DC.8-4-11b-.Sp	1.13018e-10	0.457313	False
Tgd.Th	1.11455e-10	0.460091	False
Mo.6C+II-.BM	1.08068e-10	0.463976	False
T.8Eff.Sp.OT1.24hr.LisOva	8.54629e-11	0.466233	False
T.4Mem49d+11a+.Sp.d30.LCMV	7.89177e-11	0.473435	False
B1a.Sp.v2	3.2392e-11	0.48643	False
MF.Medl.SLN	2.53472e-11	0.490241	False
NK.DAP12-.Sp	-5.00471e-12	0.501906	False
CD8.96h.LN	-1.65316e-11	0.506206	False
T.4FP3-.Sp	-1.81064e-11	0.507399	False
proB.FrBC.FL	-2.79127e-11	0.509509	False
ILC1.CD127+.SI	-3.14393e-11	0.510911	False
Mo.6C-II+.Bl	-3.78213e-11	0.512866	False
NK.49H+.Sp	-5.67399e-11	0.520969	False
MF.AT.v2	-5.77304e-11	0.521918	False
NK.DAP10-.Sp	-7.12295e-11	0.525691	False
T.8Eff.Tbet+.Sp.OT1.d6LisOVA	-8.4177e-11	0.526534	False
T.8SP69+.Th	-7.03116e-11	0.529379	False
T.4.PLN.BDC	-7.59839e-11	0.529469	False
Ep.8wk.MEClo.Th	-9.31015e-11	0.539464	False
Tgd.vg4+24alo.e17.Th	-9.9586e-11	0.539884	False
proB.FrA.FL	-1.52676e-10	0.552787	False
ILC1.CD49b-.Lv	-1.41461e-10	0.554981	False
Ep.8wk.MEChi.Th	-1.29862e-10	0.556349	False
proB.FrA.BM	-1.53899e-10	0.557233	False
SC.GMP.BM	-2.05005e-10	0.565818	False
T.8Eff.Sp.OT1.d8.LisOva	-2.00546e-10	0.570362	False
T.4Nve.PP	-1.72633e-10	0.570805	False
preB.FrC.BM	-2.57256e-10	0.594275	False
Ep.8wk.CEChi.Th	-2.78428e-10	0.609361	False
ILC3.NKp46-.4-.SI	-3.15513e-10	0.619288	False
proB.CLP.FL	-4.47209e-10	0.649521	False
Tgd.vg3+24alo.e17.Th	-4.12248e-10	0.64974	False
T.8Mem.Sp.OT1.d106.VSVOva	-3.95006e-10	0.654085	False
Ep.5wk.MEChi.Th	-3.65772e-10	0.654546	False
CD4.96h.LN	-4.49086e-10	0.659645	False
MF.Thio5.II-480int.PC	-4.96007e-10	0.67019	False
SC.CDP.BM	-4.89963e-10	0.680569	False
GN.Bl.v2	-4.97449e-10	0.682748	False
MF.Thio5.II+480int.PC	-5.50925e-10	0.693902	False
DC.8-.Th	-5.24461e-10	0.695237	False
Ep.8wk.CEC.Sca1+.Th	-5.43193e-10	0.708649	False
T.DP.69-.e17.Th.v2	-6.49963e-10	0.709495	False
MEChi.GFP-.Adult	-5.35849e-10	0.713095	False
T.4Eff49d+11a+.Sp.d8.LCMV	-7.11802e-10	0.725483	False
GN.Bl	-6.36567e-10	0.728475	False
Ep.5wk.MEC.Sca1+.Th	-5.93816e-10	0.73105	False
DC.11b+.AT.v2	-5.92645e-10	0.731583	False
SC.STSL.BM	-6.4446e-10	0.731747	False
Tgd.vg2+24ahi.e17.Th	-7.09412e-10	0.731891	False
Ep.5wk.MEClo.Th	-5.88207e-10	0.734824	False
MF.Thio5.II+480lo.PC	-6.88645e-10	0.740469	False
ILC3.NKp46+.Rorgthi.SI	-7.21114e-10	0.741073	False
Tgd.vg1+vd6+24alo.Th	-6.1718e-10	0.750055	False
MEChi.GFP+.Adult	-6.20381e-10	0.750912	False
preB.FrD.BM	-6.23544e-10	0.751793	False
T.DN4.Th	-7.13832e-10	0.758296	False
SC.MPP34F.BM	-7.07009e-10	0.759997	False
GN.Arth.BM	-7.45384e-10	0.760289	False
ILC3.NKp46-.4+.SI	-7.19197e-10	0.763798	False
NK.CD127-.SI	-8.56889e-10	0.76855	False
T.8Eff.Sp.OT1.d6.LisOva	-7.95874e-10	0.775077	False
MC.Es	-7.73594e-10	0.784658	False
NK.MCMV7.Sp	-8.55141e-10	0.791912	False
MF.F480hi.ctrl.PC	-8.14637e-10	0.797638	False
MF.Alv.Lu	-8.01235e-10	0.803746	False
NK.49H-.Sp	-8.65573e-10	0.806563	False
Ep.MEChi.Th	-8.17701e-10	0.807347	False
DC.103+11b-.Lu	-9.21675e-10	0.817475	False
Tgd.vg2-.Sp.TCRbko	-9.72148e-10	0.823177	False
LEC.SLN.OT	-9.34972e-10	0.823615	False
DC.LC.Sk	-9.27417e-10	0.825175	False
preT.DN2A.Th	-9.51016e-10	0.826657	False
CD4.1h.LN	-1.03087e-09	0.833115	False
Tgd.vg5+24ahi.Th	-1.13153e-09	0.836263	False
T.8Eff.Sp.OT1.48hr.LisOva	-1.0239e-09	0.850322	False
MLP.BM	-1.16895e-09	0.856026	False
MF.PPAR-.Lu	-9.95813e-10	0.85638	False
SC.MDP.BM	-1.15227e-09	0.859935	False
T.8Eff.Sp.OT1.d5.VSVOva	-1.11235e-09	0.863424	False
MF.Thio5.II-480hi.PC	-1.16245e-09	0.870518	False
SC.STSL.FL	-1.18469e-09	0.879493	False
ILC2.SI	-1.29955e-09	0.880254	False
FRC.SLN.CFA.d6.v2	-1.13803e-09	0.881551	False
Tgd.vg3+24ahi.e17.Th	-1.15579e-09	0.902648	False
T.8EffKLRG1+CD127-.Sp.d8.LisOVA	-1.39262e-09	0.904001	False
NKT.44+NK1.1-.Th	-1.32948e-09	0.914641	False
MC.Tr	-1.32867e-09	0.916115	False
GN.BM	-1.43907e-09	0.922914	False
MF.II-480hi.PC	-1.39972e-09	0.925878	False
LEC.SLN.v2	-1.49899e-09	0.928504	False
MF.F480hi.Gata6ko.PC	-1.49833e-09	0.930019	False
Eo.BL.v2	-1.42287e-09	0.931417	False
MLP.FL	-1.72321e-09	0.936961	False
SC.MEP.BM	-1.67108e-09	0.943191	False
Tgd.vg1+vd6+24ahi.Th	-1.81058e-09	0.943714	False
MC.digest.PC	-1.44536e-09	0.948915	False
FRC.SLN.v2	-1.58795e-09	0.953513	False
LEC.SLN	-1.70275e-09	0.956407	False
BA.Sp	-1.71564e-09	0.957411	False
MF.Lu	-1.60931e-09	0.957902	False
SC.LT34F.BM	-1.73838e-09	0.963473	False
LEC.MLN	-1.72427e-09	0.965052	False
SC.LTSL.FL	-2.05273e-09	0.968595	False
LEC.SLN.CFA.d6.v2	-1.74297e-09	0.970364	False
DN.SLN.CFA.d6.v2	-1.81118e-09	0.970905	False
BEC.SLN	-1.98236e-09	0.979566	False
BA.Bl	-1.99797e-09	0.979653	False
BEC.SLN.OT	-1.99332e-09	0.980947	False
NK.CD127-.Sp	-2.13674e-09	0.981846	False
DN.SLN.v2	-1.93877e-09	0.982231	False
EO.AT.v2	-2.20661e-09	0.982489	False
SC.ST34F.BM	-2.33969e-09	0.987091	False
BEC.MLN	-2.17623e-09	0.991383	False
FRC.Cad11.WT.v2	-2.17832e-09	0.991455	False
Tgd.vg1+vd6-24ahi.Th	-2.53503e-09	0.992842	False
MC.Sk	-2.18897e-09	0.992952	False
FRC.MLN	-2.58885e-09	0.995188	False
FRC.SLN	-2.50678e-09	0.995518	False
SC.CMP.BM.DR	-2.93272e-09	0.996401	False
St.31-38-44-.SLN	-2.87805e-09	0.997437	False
Fi.Sk	-2.62676e-09	0.998084	False
MC.To	-2.59223e-09	0.998204	False
MC.PC	-2.68177e-09	0.998382	False
Fi.MTS15+.Th	-2.74863e-09	0.99883	False
NK.CD49b+.Lv	-2.99514e-09	0.998939	False
FRC.SLN.OT	-2.82216e-09	0.998977	False

Corces et al. ATAC-seq data

The results of applying S-LDSC using the epigenetic reference data from Corces et al. ATAC-seq analysis of blood cells are shown in the expandable table below. There are no significant cell types.

Corces et al. ATAC-seq — full results

Name	Coefficient	Coefficient_P_value	Reject Null
Erythro	1.81316e-08	0.157605	False
Bcell	4.75424e-09	0.347373	False
CLP	4.75201e-09	0.372978	False
Mono	-8.85475e-10	0.517616	False
MEP	-1.60751e-09	0.569209	False
CD4	-4.34861e-09	0.621043	False
CD8	-6.08587e-09	0.660295	False
LMPP	-9.06852e-09	0.720388	False
CMP	-6.34609e-09	0.7284	False
GMP	-9.00096e-09	0.768934	False
HSC	-8.62618e-09	0.783665	False
MPP	-8.66771e-09	0.787535	False
NK	-2.93982e-08	0.991218	False

Cahoy and GTEx-Brain data

The next two reference datasets pertain to the nervous system.

Surprisingly, when we analyze the DecodeME results using the Cahoy dataset, the neuron cell type is not even close to being significant. This is discordant with some of the results above, in which many CNS-related cell and tissue types were marked as significant. Moreover, the oligodendrocyte cell type is closer to being significant than the neuron cell type.

Cahoy — full results

Name	Coefficient	Coefficient_P_value	Reject Null
Oligodendrocyte	2.12587e-09	0.0298859	False
Neuron	1.20664e-09	0.102184	False
Astrocyte	-9.48532e-10	0.825935	False

When we use the GTEx brain reference dataset, the cortex tissue type is significant. See the expandable table.

GTEx brain — full results

Name	Coefficient	Coefficient_P_value	Reject Null
Brain_Cortex	3.27302e-09	0.000106162	True
Brain_Frontal_Cortex_(BA9)	2.09938e-09	0.00639403	False
Brain_Anterior_cingulate_cortex_(BA24)	1.48503e-09	0.027612	False
Brain_Nucleus_accumbens_(basal_ganglia)	1.14202e-09	0.112643	False
Brain_Cerebellum	8.86835e-10	0.186965	False
Brain_Hippocampus	3.52484e-10	0.331468	False
Brain_Putamen_(basal_ganglia)	3.49841e-10	0.35174	False
Brain_Cerebellar_Hemisphere	2.47904e-10	0.391584	False
Brain_Amygdala	1.38265e-10	0.428756	False
Brain_Caudate_(basal_ganglia)	-8.02142e-11	0.536922	False
Brain_Spinal_cord_(cervical_c-1)	-2.96785e-10	0.630654	False
Brain_Hypothalamus	-9.28037e-10	0.844904	False
Brain_Substantia_nigra	-1.09935e-09	0.905791	False

How to Reproduce This

To reproduce, run the DecodeME Analysis Script.

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1. Hilary K Finucane, Yakir A Reshef, Verneri Anttila, Kamil Slowikowski, Alexander Gusev, Andrea Byrnes, Steven Gazal, Po-Ru Loh, Caleb Lareau, Noam Shoresh, and others. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nature Genetics, 50(4):621–629, 2018. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC5896795/. ↩

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