mecfs_bio.build_system.task.ppp_ldsc

Modules:

• batched_ldsc_h2 –

  Batched univariate LD-score-regression heritability for the UKB-PPP database.

• batched_ldsc_rg –

  Batched cross-trait LD-score-regression genetic correlation for the UKB-PPP database.

• gene_coords –

  Gene coordinates per Olink protein, read from the Sun et al. 2023 supplementary table ST3.

• ppp_ldsc_context –

  Shared, protein-invariant context for LDSC over the UKB-PPP database.

• ppp_protein_heritability_task –

  Per-protein SNP heritability for the UKB-PPP database via batched LD-score regression.

• ppp_protein_rg_task –

  Cross-trait genetic correlation of one trait against every UKB-PPP protein via LD-score regression.

• trait_alignment –

  Align an external trait's signed z-score onto the shared UKB-PPP LDSC context SNP set.